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Opportunity details

What is the effectiveness and safety of levetiracetam as first line treatment for neonatal seizures compared to phenobarbital?

Invitation to review a potential NHS research priority

Link to organisation:

Full description:

There has been little good quality evidence on which to base management of neonatal seizures. Primary management has remained unchanged for many years with phenobarbital the usual drug of choice.

The available evidence points towards levetiracetam being effective and safe for the treatment of neonatal seizures but the quality and size of previous studies has not been adequate to date.

Patient group: Term or preterm neonates (28 days or younger)

Date from

5th July 2018

Date to

11th July 2019


University of Southampton

The NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC), based at the University of Southampton, manages evaluation research programmes and activities for the National Institute for Health Research (NIHR), and plays an important role in improving the health and wealth of the nation through research.
NETSCC is part of the Wessex Institute, and has been contracted by the Department of Health and Social Care to manage evaluation research programmes.



Children and young people


All of England

Involvement type:


What support is offered?

Advise on process




Not applicable

Can the work be done from home?


Suitable for a beginner?


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